Products  /  Discovery
Ozette Discovery · Includes Resolve + Endpoints

Find the biology your trial wasn't looking for.

Your trial measured the endpoints you pre-defined — but the data holds far more. Discovery explores it all, surfaces the populations you missed, and feeds new biomarkers back into your next study.

app.ozette.com / discovery · study ONC-204
Cell embedding colored by phenotype — every population annotated
HLADR+ CD11C+ CD14+
Discovered populations
CD8+ Tem8.4%
CD4+ Treg1.6%
NK CD56dim8.1%
Classical mono13.2%
Memory B cells2.4%
Polyfunctional CD8+ T0.3%NOVEL
Why it matters

Your trial only measured what you knew to ask.

Pre-defined endpoints answer the question you set out with — but the most important biology is often the part you didn't anticipate.

01

You measured a slice

Endpoints capture pre-specified readouts. Everything else in the sample goes unexamined.

02

The signal hides in the rest

Rare and unexpected populations — often the ones that explain response — never surface under a fixed gating template.

03

Insight comes too late

By the time you'd re-analyze by hand, the trial is closed and the next one is already designed.

What Discovery does

Unbiased exploration of every population in your data.

No gating template, no prior hypothesis. Discovery annotates every robust population in the sample — so the biology you didn't predict can finally show up.

Every population, annotated

AI-driven annotation across the full sample — not just the gates you drew.

Rare & novel phenotypes

Surfaces the low-frequency populations a manual template was never designed to see.

Unbiased by design

Hypothesis-free exploration removes the assumptions baked into manual gating.

Feeds back into Endpoints

Promote what you find into pre-defined endpoints for your next trial.

On clean, analyzed data

Includes Resolve and Endpoints, so unmixing and analysis are handled underneath.

Days, not months

Explore the full depth of a study without a manual re-analysis project.

The discovery loop

Each trial makes the next one sharper.

Discovery turns a finished study into the starting point for a better one.

Step 1

Run the trial

Collect samples and measure your pre-defined biomarker endpoints.

Step 2

Endpoints

Automated, reproducible readouts on the questions you set out with.

Step 3

Discovery

Explore everything you didn't pre-specify — surface what you missed.

Step 4

Next trial

Promote new biomarkers into Endpoints and stratify the next study.

Insights feed back into Endpoints — and into your next trial.
Every population annotated
Rare & novel phenotypes surfaced
Unbiased — no template
Days, not months
Proof in the science

What teams have found with Discovery.

Response

Predicting immunotherapy response

In Merkel cell carcinoma and melanoma — phenotypes linked to response, benchmarked against conventional analysis.

View case study →
Novel

A suppressive T-cell population

Discovery surfaced a population in the tumor microenvironment that dampens immune response — informing IO drug development.

View case study →
Re-analysis

Structure missed in published data

Re-analysis of a published COVID-19 dataset surfaced populations the original manual workflow didn't capture.

View case study →
Where Discovery sits

The top tier — it includes everything below.

Discovery builds on Endpoints and Resolve, on one data model. Your unmixing and endpoint analysis are already handled — Discovery adds unbiased, full-depth exploration on top.

Discovery

Biomarker discovery & exploration

You are here

Endpoints

Automated trial biomarker analysis

Tier 2 · included

Resolve

Adaptive spectral unmixing

Tier 1 · included
Two ways to run it

Explore it yourself, or have us run it.

Self-serve software

Your team explores

Run Discovery on your own data — buy a license and pay only for the files you process. We onboard and train your team.

  • Includes Resolve + Endpoints
  • License + pay-per-file
  • Onboarding & training included
Managed service + Ozette Lab

We deliver the findings

Our scientists run the exploration end to end and deliver the populations and biomarkers worth carrying into your next trial.

  • Expert-led exploration
  • Optional data generation by the Lab
  • Delivered under a validated quality system
Get started

Find what your last trial missed.

Bring a finished study — we'll show you what unbiased exploration surfaces.