Effective comparison of single-cell embedding visualizations.

August 10, 2023

At ISMB 2023, Ozette’s Trevor Manz lead a lively panel on effective comparison of single-cell embedding visualizations. To better understand the approach, challenges, and conclusions, learn more by downloading the event poster here.

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Automated gating and antigen-specific T cells subset discovery using FAUST and COMPASS on ICS data.

August 8, 2023

At ISMB 2022, Ozette Computational Biologist Malisa Smith, and Ozette Co-Founder Evan Greene, PhD VP of Quantitative Methods discussed automated gating and antigen-specific T cells subset discovery using FAUST and COMPASS on ICS data as well as how they reanalyzed a published Intracellular Cytokine Staining (ICS) dataset. Download the poster to learn more about their presentation.

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Discovering data transformations for effective visualization of single-cell embeddings.

August 3, 2023

At ISMB 2022, Ozette’s Fritz Lekschas, PhD, Head of Visualization Research lead a fascinating discussion about data transformations for effective visualization of single-cell embeddings. If you weren’t able to attend, take a look at this beautiful and though provoking work.

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From assay to endpoints, see how Ozette’s proprietary processes deliver results.

July 20, 2023

Recently, at CYTO 2023, we showcased how Ozette Endpoints™ and Ozette Discovery™ technologies leverage Artificial Intelligence and Machine Learning to deliver robust computational analysis pipelines and allow for rapid insights into complex high-dimensional data. View process details, methods, and case study examples in our detailed conference poster.

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Vaccination induces HIV broadly neutralizing antibody precursors in humans.

June 17, 2023

Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial...

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A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses.

May 20, 2023

The engineered outer domain germline targeting version 8 (eOD-GT8) 60-mer nanoparticle was designed to prime VRC01-class HIV-specific B cells that would need to be matured, through additional heterologous immunizations, into B cells that are able to produce broadly neutralizing antibodies. CD4 T cell help will be critical for the development of such high-affinity neutralizing antibody responses. Thus, we assessed the induction and epitope specificities of the vaccine-specific T cells...

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